Position Host institution PhD enrolment Start date Duration
ESR2 P1-USAAR Y (at USAAR) early 2017 36 months


Project Title:

Molecular and cellular mechanisms of pathological network function in mouse models of absence epilepsy


Objectives:

To evaluate the role of distinct glial transmitter receptors in the generation and duration of absence seizures in respective animal models.

 

Methodology:

Knockout mice with inducible gene deletion will be investigated by in vivo 2P-LSM using intracellular Ca2+ as indicator of glial network activity. After induced gene ablation, chemical seizures will be evoked. Ca2+ signals as well as EEGs will be recorded in the affected mice. In addition, molecular and immunohistochemical techniques will be applied to determine and quantify the extent of receptor knockout and subsequent changes in the adjacent neighbourhood.

 

Frank Kirchhoff
CIPMM, University of SaarlandFKirchhoff

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http://physiology.uni-saarland.de/Kirchhoff/Kirchhoff_Research.html
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