Position Host institution PhD enrolment Start date Duration
ESR4 P2-CNR Y (at U Padova/Milano) early 2017 36 months

Project Title:

Neuron-glia interactions in neurovascular coupling



Activation of astroglia by neuronal signals plays a central role in the control of cerebral blood flow (CBF, neurovascular coupling). How does epileptiform activity, in the acute and chronic state, affect Ca2+ levels in astroglial endfeet and how could a defect in astroglial activation impair the CBF response to seizures? Neurons can suffer a metabolic disruption that may firstly, impair the ability of neurons to function properly and thus leading to seizure cessation, and secondly, lead to the neuronal death associated with chronic epilepsy.



A combination of electrophysiology and Ca2+ imaging techniques at high spatial and temporal resolution will be employed to monitor simultaneously neuronal activity and Ca2+ signals of both neurons and astroglia in acute brain slices, isolated brain preparations, and in vivo experiments.


Giorgio CarmignotoGCarmignoto
Consiglio Nazionale delle Ricerche

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