Position | Host institution | PhD enrolment | Start date | Duration |
ESR7 | P5-INSERM | Y (at U Paris) | early 2017 | 36 months |
Ca2+ signalling and motility of microglial cells Giorgio Cignitti |
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Methodology: New genetic and imaging tools will be used to study Ca2+ signals of microglia in situ and in vivo in response to neuronal activity and during their tissue surveillance. A combination of electrophysiological (patch clamp) and imaging (video microscopy, 2P-LSM) techniques will be used in acute cortical slices and in vivo. We will first identify the signalling pathways responsible for the recruitment of microglia at maturating synapses. We will then study how an inflammatory challenge and febrile seizures influence interactions between neurons and microglia during cortical development.
Etienne Audinat This email address is being protected from spambots. You need JavaScript enabled to view it. |